Solvents develop a pivotal role in the pharmaceutical industry considering that they may account up to 90% of drug delivery operations. The development of new solvents for pharmaceutical applications, especially for active pharmaceutical ingredients (API), is a pivotal task in order to improve API purification by crystallization, to develop API controlled release applications, to increase API active concentration (i.e. bioavailability), and thus to design more efficient drug delivery methods. Therefore, the design and selection new solvents are required for developing sustainable pharmaceutical processes considering the large quantities of solvents required for APIs production and purification, which in turns leads to the very large E-factor for pharmaceutical industries. We recently launched a project on developing novel solvents to tackle this problem.